Yusei was born in the Tops area of New Domino City. His parents were lead developers for the Ener-D Reactor. Dr. Fudo named his son Yusei after the Planetary Particle (Yuusei Ryuushi), as he wished for Yusei to be able to connect people with bonds. As the Zero Reverse was about to take place, before dying, Yusei's father placed Yusei in an escape pod, saving him from the disaster that would follow. Yusei's parents were both killed in the Zero Reverse and Yusei was sent to an orphanage in Satellite, where he was fostered by Martha. Growing up he was interested in auto shop and Jack defended him and his friends from bullies.
Yusei grew up in Satellite, where he befriended Kalin Kessler, Jack Atlas, and Crow Hogan. As residents of Satellite, they were made to do labor for the residents of New Domino City and denied many luxuries, often enjoyed in New Domino.
Yusei Fudo's Deck uses many speed themed cards and revolves around the Synchro Summoning of the "Warrior" Synchro Monsters, "Junk", "Nitro", "Drill", "Turbo" and "Road", while keeping his ace card and Signer Dragon, "Stardust Dragon," in reserve for special occasions when possible. His most powerful monsters are "Majestic Star Dragon", "Dragon Knight Draco-Equiste", "Shooting Star Dragon", and "Shooting Quasar Dragon". Most of his non-Synchro Monsters are low in Level, giving him more fine control over which Synchro Monster he is able to summon at a given time. His basic strategy usually entails either swarming the field with many low-level monsters all at once for a high-level Synchro Summon or else using his lower-level Synchro Monsters as a bridge to summon the higher-level ones.